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Radiopharmaceutical Doses

For medical treatment and diagnosis, radioactivity is often administered to a patient as part of the process.  In Publication 53, the International Commission on Radiological Protection (ICRP) has summarized the effective dose equivalent associated with unit administrations of various radiopharmaceuticals. These factors are useful for estimating the radiation dose to healthy individuals who resemble “Reference Man”. (For your information, Reference Man is a hypothetical individual with well-defined values for daily intakes of air and water or carrier elements, breathing rates, excretion rates, organ sizes, metabolic features, and other physical parameters. You can learn more about him by going to the “Reference Values” category of the Plexus-NSD web page.)

The following is a listing of selected ICRP 53 dose factors, ordered by element.  Each listing shows the radionuclide, the radiopharmaceutical, and the dose per unit administration, in units of “millirem per microcurie”. Unless shown otherwise, the mode of administration is intraveneous.                                                                                                                                                                                                            

Arsenic

  • As-74 – Arsenate – 2.33352
  • As-76 – Arsenate – 1.44456

Barium

  • Ba-131 – Ba-labelled Non-absorbable Markers – 1.66680
  • Ba-135m – Barium – 1.14824

Bromine

  • Br-77 – Bromospiperone – 0.32225
  • Br-77 – Bromide – 0.28891
  • Br-82 – Bromide – 1.59272

Calcium

  • Ca-45 – Calcium (oral) – 4.44480
  • Ca-47 – Calcium (oral) – 5.92640

Carbon

  • C-11 – Spiperone – 0.02185
  • C-11 – Carbon Dioxide (inhalation) – 0.00630
  • C-11 – COHb-labelled Erythrocytes – 0.02556
  • C-11 – Carbon Monoxide  (inhalation) – 0.02445
  • C-14 – Inulin – 0.04074

Cesium

  • Cs-129 – Caesium – 0.17409
  • Cs-130 – Caesium – 0.00889
  • Cs-131 – Caesium – 0.18150

Chlorine

  • Cl-34m – Chloride – 0.03185
  • Cl-36 – Chloride – 2.96320
  • Cl-38 – Chloride – 0.05926

Chromium

  • Cr-51 – Cr-labelled White Blood Cells – 0.70376
  • Cr-51 – Cr-labelled Non-absorbable Markers – 0.12594
  • Cr-51 – Cr-labelled Denatured Erythrocytes – 1.48160
  • Cr-51 – Cr-labelled Erythrocytes – 0.96304
  • Cr-51 – Chromium (III) Chloride – 0.40744
  • Cr-51 – Chromium EDTA – 0.00852
  • Cr-51 – Cr-labelled Platelets – 0.88896

Cobalt

  • Co-57 – Co-labelled Bleomycin – 0.20742
  • Co-57 – Vitamin B12 (oral) – 14.81600
  • Co-57 – Vitamin B12 – 21.48320
  • Co-58 – Vitamin B12 (oral) – 27.78000
  • Co-58 – Vitamin B12 – 40.74400

Copper

  • Cu-64 – Copper – 0.19631
  • Cu-67 – Copper – 0.81488

Fluorine

  • F-18 – Fluoride – 0.10001
  • F-18 – 2-Fluoro-2-Deoxy-d-Glucose – 0.10001

Gallium

  • Ga-66 – Gallium Citrate – 1.25936
  • Ga-67 – Gallium Citrate – 0.44448
  • Ga-68 – Gallium Citrate – 0.10001
  • Ga-72 – Gallium Citrate – 1.29640

Gold

  • Au-198 – Gold Colloid – 5.55600

Hydrogen

  • H-3 – Inulin – 0.00444
  • H-3 – Water – 0.05926

Indium

  • In-111 – In-labelled Aerosols – 0.10371
  • In-111 – In-labelled Platelets – 2.59280
  • In-111 – In-labelled Bleomycin – 0.59264
  • In-111 – In-labelled White Blood Cells – 2.18536
  • In-111 – In-labelled Non-absorbable Markers – 1.11120
  • In-111 – Indium-DTPA – 0.09260
  • In-111 – Indium – 0.96304
  • In-113m – Indium Hydroxide (Colloidal) – 0.06297
  • In-113m – In-labelled Non-absorbable Markers – 0.10371
  • In-113m – In-labelled Aerosols – 0.06667
  • In-113m – Indium-DTPA – 0.05186
  • In-113m – Indium – 0.04815

Iodine

  • I-123 – I-labelled Albumin – 0.09630
  • I-123 – Iodide (25% uptake) – 0.40744
  • I-123 – I-labelled Fibrinogen – 0.10001
  • I-123 – I-labelled Amphetamine – 0.11853
  • I-123 – Iodide (5% uptake) – 0.14075
  • I-123 – Hippuran – 0.05556
  • I-123 – I-labelled Microaggregated Albumin – 0.08890
  • I-123 – Iodide (35% uptake) – 0.55560
  • I-123 – Iodide (55% uptake) – 0.85192
  • I-123 – Iodide (45% uptake) – 0.70376
  • I-123 – I-labelled Non-absorbable Markers – 0.55560
  • I-123 – Iodide (0% uptake) – 0.04815
  • I-123 – Sodium rose Bengal – 0.28150
  • I-123 – Iodide (15% uptake) – 0.27780
  • I-124 – Iodide (0% uptake) – 0.40744
  • I-124 – Iodide (55% uptake) – 51.85600
  • I-125 – I-labelled Fibrinogen – 0.44448
  • I-125 – Iodide (0% uptake) – 0.04445
  • I-125 – I-labelled Albumin – 1.25936
  • I-125 – Hippuran – 0.03704
  • I-125 – Iodoantipyrine – 0.04815
  • I-125 – Iodide (55% uptake) – 59.26400
  • I-125 – Iothalamate – 0.03593
  • I-125 – Thyroxine (T4) – 0.44448
  • I-131 – Iodoantipyrine – 0.28891
  • I-131 – I-labelled Albumin – 3.18544
  • I-131 – I-labelled Macroaggregated Albumin – 1.85200
  • I-131 – I-labelled Fibrinogen – 2.07424
  • I-131 – Iodide (55% uptake) – 88.89600
  • I-131 – Iodide (0% uptake) – 0.26669
  • I-131 – Thyroxine (T4) – 1.62976
  • I-131 – I-labelled Non-absorbable Markers – 3.44472
  • I-131 – I-labelled Microaggregated Albumin – 1.14824
  • I-131 – Hippuran – 0.24446

Iron

  • Fe-52 – Iron – 3.70400
  • Fe-52 – Iron (oral) – 1.81496
  • Fe-55 – Iron – 21.85360
  • Fe-55 – Iron (oral) – 2.18536
  • Fe-59 – Iron (oral) – 7.40800
  • Fe-59 – Iron – 48.15200

Krypton

  • Kr-81m – Krypton (inhalation) – 0.00010

Lanthanum

  • La-140 – Lanthanum-DTPA – 0.70376

Magnesium

  • Mg-28 – Magnesium – 3.07432

Mercury

  • Hg-197 – Chlormerodrin – 0.66672
  • Hg-197 – Bromo-Mercuri-Hydroxypropane – 1.44456
  • Hg-197 – Mercury (II) Chloride – 1.18528
  • Hg-203 – Chlormerodrin – 6.29680

Nitrogen

  • N-13 – Nitrogen Gas in Solution – 0.00148
  • N-13 – Nitrogen Gas (inhalation) – 0.00137
  • N-13 – Ammonia – 0.01000
  • N-13 – l-Glutamate – 0.04815

Oxygen

  • O-15 – Carbon Monoxide (inhalation) – 0.00407
  • O-15 – Carbon Dioxide (inhalation) – 0.00200
  • O-15 – Oxygen Gas (inhalation) – 0.00144

Phosphorus

  • P-32 – Phosphate – 8.14880
  • P-33 – Phosphate – 1.22232

Potassium

  • K-38 – Potassium – 0.10001
  • K-42 – Potassium (oral) – 0.85192
  • K-43 – Potassium (oral) – 0.66672

Rubidium

  • Rb-81 – Rb-labelled Denatured Erythrocytes – 1.00008
  • Rb-81 – Rubidium – 0.11482
  • Rb-82 – Rubidium – 0.01778
  • Rb-84 – Rubidium – 13.33440
  • Rb-86 – Rubidium – 14.44560

Scandium

  • Sc-46 – Sc-Labelled Non-absorbable Markers (fluids) – 5.18560
  • Sc-46 – Sc-Labelled Non-absorbable Markers (solids) – 5.55600
  • Sc-47 – Sc-Labelled Non-absorbable Markers (fluids) – 2.07424
  • Sc-47 – Sc-Labelled Non-absorbable Markers (solids) – 2.11128

Selenium

  • Se-75 – Se-labelled Bile Acid – 4.07440
  • Se-75 – Selenite – 12.96400
  • Se-75 – 1-Selenomethionine – 11.11200
  • Se-75 – Selenomethylcholesterol – 6.29680

Sodium

  • Na-22 – Sodium (IV) – 10.37120
  • Na-24 – Sodium (oral) – 1.33344

Strontium

  • Sr-85 – Strontium – 3.14840
  • Sr-87m – Strontium – 0.02482
  • Sr-89 – Strontium – 10.74160

Sulfur

  • S-35 – Sulphate – 0.36299

Technetium

  • Tc-99m – Tc-labelled White Blood Cells – 0.06297
  • Tc-99m – Tc-labelled Platelets – 0.08149
  • Tc-99m – Tc-labelled Aerosols – 0.02593
  • Tc-99m – Tc-lebelled Phosphates – 0.02963
  • Tc-99m – Tc-labelled Heparin – 0.02704
  • Tc-99m – Tc-labelled Erythrocytes – 0.03148
  • Tc-99m – Tc-labelled Fibrinogen – 0.03000
  • Tc-99m – Tc-labelled Iminodiacetic Acid Derivatives – 0.12594
  • Tc-99m – Pertechnetate – 0.04815
  • Tc-99m – Tc-labelled Denatured Erythrocytes – 0.15186
  • Tc-99m – Tc-Gluconate, Glucoheptonate – 0.03334
  • Tc-99m – Tc-labelled Small Colloids – 0.05186
  • Tc-99m – Tc-labelled Plasmin – 0.04074
  • Tc-99m – Technetium-DTPA – 0.02334
  • Tc-99m – Technetium-DMSA – 0.05926
  • Tc-99m – Tc-labelled citrate Complex – 0.03074
  • Tc-99m – Tc-labelled Large Colloids – 0.05186
  • Tc-99m – Technetium-Penicillamine – 0.04815
  • Tc-99m – Tc-labelled Albumin – 0.02926

Thallium

  • Tl-201 – Thallium – 0.85192

Xenon

  • Xe-127 – Xenon Gas (inhalation) – 0.00052

Ytterbium

  • Yb-169 – Ytterbium-DTPA – 0.17038

Zinc

  • Zn-62 – Zinc – 1.81496
  • Zn-65 – Zinc – 40.74400
  • Zn-69m – Zinc – 0.77784